Kangerlussuaq Fjord is located on the east coast of Greenland. It is approximately midway between Scoresby Sund and Sermilik Fjord and marks the southern extent of the Blosseville Coast.

It is the second-largest fjord in the southeastern coast of Greenland with its waters being fed by the Kangerlussuaq Glacier.

There is also a Kangerlussuaq Fjord on the west coast of Greenland.